You may feel some discomfort when the needle (cannula) is initially inserted, but once the chemotherapy is running, you shouldn’t feel any pain. Please let your treating nurse know if you are experiencing any pain during your infusion. If you have a central venous access device (CVAD), there should be no pain either. Again, please let your treating nurse know if you are experiencing any pain around your line. Some chemotherapy drugs can cause inflammation of the veins (phlebitis) which can cause some discomfort for a few days.